Improving the bioavailability of poorly soluble medicinal products – solid dispersions in medicine and pharmacy

Project leaderSc.D. in Pharmaceutical SciencesHead of the Department, Professor, Ph.D. in Pharmaceutical SciencesAssociate Professor, Ph.D. in Pharmaceutical SciencesAssociate Professor, Ph.D. in Pharmaceutical SciencesAssociate Professor, Ph.D. in Pharmaceutical SciencesAssociate Professor, Assistant, Postgraduate student, Postgraduate student, Postgraduate student

Goal

To develop innovative medicinal products (including fast dissolving ones) containing solid dispersions (SD) of low solubility active pharmaceutical substances (APS) with improved biopharmaceutical properties

Key objectives

screening of low solubility APS in water and optimal carrier polymers for preparing SD
development of technology for producing SD of the studied APS
development of the composition and technology for producing innovative medicinal products using previously developed SD
standardization of the obtained preparations, assessment of bioavailability, stability, and shelf life during storage

Partner organizations

Department of Pharmaceutical Technology of the Institute of Pharmacy, Sechenov First Moscow State Medical University (Sechenov University)
Laboratory of Pharmaceutical Technologies at the Scientific and production site of the Center for Regenerative Medicine, Lomonosov Moscow State University

Publications

The effect of solid dispersions on the solubility of tamsulosin hydrochloride in an aqueous medium. Research J. Pharmacy and Technology. 2026. Т. 19. № 3. P. 1260-1264. https://doi.org/10.52711/0974-360X.2026.00180
Study of the effect of solid dispersions with polyvinylipyrrolidone-10000 on the dissolution of nimesulid. Farmatsiya. 2026. Т. 75. № 5. P. 37-45. https://doi.org/10.29296/25419218-2026-05-04
Increasing the solubility of albendazole by solid dispersion method. Farmatsiya. 2026. Т. 75. №. 3. P. 57-64. https://doi.org/10.29296/25419218-2026-03-08
Influence of solid dispersions on the solubility of tamsulosin hydrochloride. Farmatsiya. 2025. Т. 74. № 2. P. 38-45. https://doi.org/10.29296/25419218-2025-02-05
Study of the specific activity of an innovative dosage form of a chemotherapeutic agent. Farmatsiya. 2022. Т. 71. № 4. P. 19-25. https://doi.org/10.29296/25419218-2022-04-03
Development of effervescent granules with solid dispersion of furazolidone. Drug development & registration. 2022. Т. 11. № 1. P. 75-81. https://doi.org/10.33380/2305-2066-2022-11-1-75-81
Development of nitrofuran derivative: composition and technology of effervescent tablets with solid dispersions. Pharmacy & Pharmacology. 2022. Т. 10. №. 1. P. 55-68. https://doi.org/10.19163/2307-9266-2022-10-1-55-68
Effect of solid dispersions on the solubility of metronidazole. Pharmacy & Pharmacology. 2021 Т. 9. № 3. P. 195-204. https://doi.org/10.19163/2307-9266-2021-9-3-195-204