Objective: Antimicrobial resistance (AMR) represents a significant worldwide health concern, contributing significantly to morbidity and mortality. Methicillin-resistant Staphylococcus aureus (MRSA) is accountable for a plethora of infections, ranging from minor cutaneous manifestations to grave metastatic conditions. The dissemination of MRSA among cancer patients poses a substantial public health hazard on a global scale.
This study explores the association between MRSA and bacteriophage-encoded immune evasion cluster (IEC) genes. rates.

Objective: Diabetes is a long-term health condition where blood sugar levels are consistently too high. This happens when the body either doesn’t produce enough insulin or can’t use it properly. Over time, this can lead to serious complications, including slow wound healing and heart problems. Hyperbaric Oxygen Therapy (HBOT) is a treatment where people breathe pure oxygen in a controlled, pressurized environment. This helps improve the flow of oxygen to tissues, speeding up healing, reducing inflammation, and improving blood circulation. For people with diabetes, HBOT has shown promise in improving heart health and dealing with circulation problems and heart disease. The therapy works by supporting tissue repair, boosting oxygen delivery, and helping the heart function better. Research on diabetic rats may help us better understand how HBOT could reduce heart-related issues for people with diabetes, offering a hopeful approach to managing the cardiovascular risks that come with the condition.

Objective: Cardiovascular disorders represent severe complications of rheumatoid arthritis (RA) that can contribute to the mortality of RA patients. Oxidative stress has one of the main role in the development of RA and its complications. Curcumin, polyphenol from Curcuma longa, is a potent scavenger of variety reactive oxygen species with antioxidant activity.
The aim of this study was to examine potential role of curcumin in reduction of oxidative stress and cardiovascular risk in RA.

Objective: The aim of the study was to examine regional features of the elemental status of the population of Yakutia. To solve the problem, an assessment of elements in the spectral analysis of hair was used.

Objective: Methicillin-resistant Staphylococcus aureus (MRSA) is associated with multidrug- resistant (MDR) infections, necessitating the development of novel antimicrobial compounds. Bacteriocins are antimicrobial peptides produced by human microbiota to combat pathogens.
This study aimed to explore the potential activity of bacteriocins against clinical isolates of MRSA. We isolated 203 bacteria from the skin and oral cavity microbiota of healthy individuals and screened them for bacteriocin production. S. aureus isolates from the microbiota were molecularly characterized for the 16S rRNA, nuc, and mecA genes. Bacteriocin extract stability was determined, and cytotoxicity was observed against the ATCC cell lines PC3, A549, and HCT116. Antibacterial activity of the extracts was monitored against 30 MRSA clinical isolates. The agar well diffusion assay showed that the six S. aureus bacteriocin extracts inhibited two MRSA clinical isolates, which were also stable at a pH of 6.5–7 and temperature of 25–30 °C, and under certain enzymatic treatments. Five bacteriocin extracts had a minimum inhibitory concentration of ≥162.5 mg/mL and one of 121.875 mg/mL (all p < 0.05).
The bacteriocins showed negligible cytotoxicity against PC3, A549, and HCT116 cell lines at a concentration of 2 μL, although a varied pattern was found at 8 μL. So in conclusion bacteriocins from the human microbiota are novel antimicrobial peptides that show remarkable action against some clinical isolates of MRSA. They have substantial potential for an alternative therapy against MDR bacteria.

Objective: an information analytical scientific literature review on genus Mentha plants.

Objective: HIV and AIDS are global problems that humanity has been facing for a long time, and their treatment requires the use of combined antiretroviral therapy, including atazanavir. However, as with any other drugs, even with strict adherence to prescribed therapy, there is a risk of poisoning with atazanavir, especially in combination with drugs of other pharmacological groups. Thus, the task of developing methods for isolating the test substance from biological materials for chemical and toxicological analysis remains very relevant.

Siberian pine (Pinus subirica du Tuor) is a promising source of a wide range of biologically active substances. Needles, roots, shoots, seeds, cones in the form of infusions and decoctions are widely used in folk medicine. While harvesting and processing pine nuts, a large amount of waste such as the pine cones peels (50% of the whole cone) is formed. The use of pinecones will solve the problem of complex processing of plant raw materials and will reduce the amount of waste generated during the harvesting of pine nut.
The main objective of the study is to determine the component composition of cones pine (Pinus sibirica du tour).

Xanthium strumarium L. is a weed annual herbaceous plant of the Asteraceae, which has spread almost all over the globe. X. strumarium fruits, included in the Chinese pharmacopoeia, has long been used in traditional Chinese medicine as an anti-inflammatory agent. The rich and diverse chemical composition determines many prospects for pharmacological use. Thus, in addition to investigation the therapeutic effects, a detailed studying of the potential toxicity of raw materials and ways to ensure safety is necessary.
Investigation of the Xanthium strumarium fruits toxicology via a toxicological research of specific toxins found in the raw materials.

The Epidemiological Wastewater Study (WBE) is a promising methodological approach for assessing the level of psychoactive substance use by the population in different regions of the world, as well as studying people's lifestyles and habits.
To study wastewater monitoring as a source of information on the health and social well-being of the population

The development of the software features for effective consecutive HRMS spectra study. The main focus is optimization and refinement of data processing algorithm.

M.D. Shvaikova emerges as a pivotal figure in the history of forensic and toxicological chemistry. While perhaps not as widely recognized as some of her contemporaries, her contributions significantly advanced the field, particularly in the development and standardization of analytical techniques. Shvaikova's work occurred during a period of significant growth and formalization of forensic science as a distinct discipline. Her research and methodological innovations laid a foundation for modern toxicological analysis, influencing generations of scientists and practitioners. Her dedication to refining existing methods and introducing new approaches helped shape the protocols and standards used in forensic laboratories.

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Purpose: To study benzodiazepine derivatives and their toxicological significance.

Purpose of the study: based on scientific and informational data search to characterize acute poisoning by GHB and its precursors and to develop a methodology for chemical and toxicologic diagnosis of poisonings.

Purpose of the study: identify diagnostic characteristics by examining the morphological and anatomical features of Aethusa cynapium L.

The aim: development of a methodology for screening 13 antidepressants in biological liquids using HPLC based on scientific review.

Purpose and objectives: To develop and validate HPLC techniques for the analysis of the substance and liposomal dosage form of acridinone derivative.

Research aim: The purpose of the study was to study the component composition of essential oil and determine the content of fatty acids in Artemisia laciniata.

PURPOSE OF THE STUDY: Development of TLC screening techniques for antiarrhythmic drugs isolated from a biological matrix.

PURPOSE OF THE STUDY: Development of an effective method for identification and quantitative determination of bisoprolol in biological fluid by gas-liquid chromatography

Aim and Objectives
This study investigates the therapeutic effects of Zuojin Pills on gastric heat syndrome in rats, focusing on:
• Suppression of pro-inflammatory cytokines (IL-2, IL-8).
• Enhancement of mucosal repair factors (PGE2 , EGF)
• Regulation of gut microbiota diversity and composition.

Introduction and aim: Enterosorbents based on lignin hydrolysed are able to adsorb different kinds of toxins in the intestine and are widely applied during the treatment of the adults. The effect of this drug consists of decrease in the intensity of endogenous toxic condition. Thus, the aim of the work is to study effect of adsorption ability of the pharmacy drugs in relation to low molecular weight toxins, toxic products of ethanol metabolism and ions of metals.

The purpose is to provide generalized and systematized information about cases of poisoning by plants growing in the territory of the Republic of Kazakhstan, the mechanisms of their toxic effect, clinical manifestations of poisoning and methods of their analysis.

Objective: To investigate the potential for false-positive detection of cannabidiol (CBD) metabolites as tetrahydrocannabinol (THC) in forensic chemical-toxicological analyses (CTA) within the Russian Federation.

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